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A Complex Role for FGF-2 in Self-Renewal, Survival, and Adhesion of Human Embryonic Stem Cells
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SYSNO ASEP 0332572 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A Complex Role for FGF-2 in Self-Renewal, Survival, and Adhesion of Human Embryonic Stem Cells Title Komplexní úloha FGF-2 v sebeobnově, přežívání a adhezi lidských embryonálních kmenových buněk Author(s) Eiselleová, L. (CZ)
Matulka, K. (CZ)
Kříž, V. (CZ)
Kunová, M. (CZ)
Schmidtová, Z. (CZ)
Neradil, J. (CZ)
Tichý, B. (CZ)
Dvořáková, D. (CZ)
Pospíšilová, Š. (CZ)
Hampl, Aleš (UEM-P)
Dvořák, Petr (UEM-P)Source Title Stem Cells. - : Oxford University Press - ISSN 1066-5099
Roč. 27, č. 8 (2009), s. 1847-1857Number of pages 11 s. Language eng - English Country US - United States Keywords fibroblast growth factor-2 ; human ESCs ; self-renewal Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50390703 - UEM-P (2007-2013) UT WOS 000270050900016 DOI 10.1002/stem.128 Annotation This study demonstrates a complex role for FGF-2 in hESCs. It shows that FGF-2 directly supports their self-renewal and stimulates cell survival and adhesion, two features that may indirectly account for undifferentiated growth. It further suggests that the action of exogenous FGF-2 is mainly to promote cell survival and adhesion while activities of endogenous FGF-2 have in addition much profound, yet underrated, impact on undifferentiated growth of hESCs Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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