Number of the records: 1

Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs

SYSNO ASEP	0332328
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs
Author(s)	Hofmanová, Jiřina (BFU-R)_{RID, ORCID} Vaculová, Alena (BFU-R)_{RID, ORCID} Koubková, Zuzana (BFU-R) Hýžďalová, Martina (BFU-R)_{RID, ORCID} Kozubík, Alois (BFU-R)_{RID, ORCID}
Number of authors	5
Source Title	Molecular Nutrition & Food Research. - : Wiley - ISSN 1613-4125 Roč. 53, č. 1 (2009), S102-S113
Number of pages	12 s.
Language	eng - English
Country	DE - Germany
Keywords	apoptosis ; butyrate ; cell differentiation
Subject RIV	BO - Biophysics
R&D Projects	GA524/07/1178 GA ČR - Czech Science Foundation (CSF)
	1QS500040507 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GA301/07/1557 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000271475300013
DOI	10.1002/mnfr.200800175
Annotation	Comparing human colon epithelial cell lines of fetal (FHC) and adenocarcinoma (HT-29, HCT-116) origin, we detected significant differences in proliferation, differentiation, and apoptotic response to the treatment of sodium butyrate (NaBt), arachidonic or docosahexaenoic acids, and their combination. Our results support the concept of modulation of NaBt effects by polyunsaturated fatty acids, especially of omega-3 type, in colonic cells in vitro with diverse impact in cell lines derived from normal or neoplastic epithelium.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1