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Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness
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SYSNO ASEP 0332245 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness Title Poškození povrchu oka u autoimunitního onemocnění suchého oka (Sjögrenův syndrom). Závažnost mikroskopických nálezů odpovídá závažnosti symptomů, zjištěných klinickým vyšetřením Author(s) Čejková, Jitka (UEM-P) RID
Ardan, Taras (UEM-P)
Čejka, Čestmír (UEM-P) RID
Malec, J. (CZ)
Jirsová, K. (CZ)
Filipec, M. (CZ)
Růžičková, E. (CZ)
Dostřelová, D. (CZ)
Brůnová, B. (CZ)Source Title Histology and Histopathology. - : Universidad de Murcia - ISSN 0213-3911
Roč. 24, č. 10 (2009), s. 1357-1365Number of pages 9 s. Language eng - English Country ES - Spain Keywords autoimmune dry eye ; oxidative injuries ; pro-inflammatory cytokines Subject RIV FF - HEENT, Dentistry R&D Projects NR8828 GA MZd - Ministry of Health (MZ) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000269079900012 Annotation Autoimmune dry eye (Sjögren´s syndrome) is a chronic disease which is characterized by inflammation of salivary and lacrimal glands leading to keratoconjunctivitis sicca. We found that oxidative injuries which appear at the ocular surface of patients suffering from this disease, are accompanied by the increase of proinflammatory cytokine exression leading to the induction of enzymatic systems that generate reactive oxygen species and nitric oxide. This results in oxidative and nitrosative stress to the eye. From clinical point of view it is important that the severity of microscopical disturbances goes parallel with the level of severity of dry eye symptoms. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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