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Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional Pt-II complexes
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SYSNO ASEP 0332052 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional Pt-II complexes Title Mechanistická studie modulace štěpící aktivity topoisomerázy I vlivem mono- a bifunkčních aduktů platnatých komplexů na DNA Author(s) Malina, Jaroslav (BFU-R) ORCID
Vrána, Oldřich (BFU-R) RID
Brabec, Viktor (BFU-R) RID, ORCIDNumber of authors 3 Source Title Nucleic Acids Research. - : Oxford University Press - ISSN 0305-1048
Roč. 37, č. 16 (2009), s. 5432-5442Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords cisplatin ; camptothecin ; topoisomerase I Subject RIV BO - Biophysics R&D Projects LC06030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ME08017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) OC08003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS500040581 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA400040803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000271569000017 DOI 10.1093/nar/gkp580 Annotation DNA adducts of bifunctional antitumor cisplatin or monodentate [PtCl(dien)]Cl (dien = diethylenetriamine) inhibit eukaryotic topoisomerase 1 (top1) action, the adducts of cisplatin being more effective. The presence of camptothecin markedly enhances effects of Pt-DNA adducts on top1 activity depending on the sequence context. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
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