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Replication of Restless Legs Syndrome Loci in Three European Populations
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SYSNO ASEP 0331384 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Replication of Restless Legs Syndrome Loci in Three European Populations Author(s) Kemlink, D. (CZ)
Polo, O. (FI)
Frauscher, B. (AT)
Gschliesser, V. (AT)
Högl, B. (AT)
Poewe, W. (AT)
Vodička, Pavel (UEM-P) RID
Vávrová, J. (CZ)
Šonka, K. (CZ)
Nevšímalová, S. (CZ)
Schormair, B. (DE)
Lichtner, P. (DE)
Silander, K. (FI)
Peltonen, L. (FI)
Gieger, C. (DE)
Wichmann, H. E. (DE)
Zimprich, A. (AT)
Roeske, D. (DE)
Müller-Myhsok, B. (DE)
Meitinger, T. (DE)
Winkelmann, J. (DE)Source Title Journal of Medical Genetics. - : BMJ group - ISSN 0022-2593
Roč. 46, č. 5 (2009), s. 315-318Number of pages 4 s. Language eng - English Country GB - United Kingdom Keywords periodic limb movements ; genetic risk-factor ; susceptibility locus Subject RIV EB - Genetics ; Molecular Biology R&D Projects NR8563 GA MZd - Ministry of Health (MZ) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000265665200004 DOI 10.1136/jmg.2008.062992 Annotation Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. Our study shows that variants in these three loci confer consistent disease risks in patients of European descent. Among the known loci, BTBD9 seems to be the most consistent in its effect on RLS across populations and is also most independent of familial clustering. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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