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Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats
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SYSNO ASEP 0330845 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats Author(s) Stofková, A. (CZ)
Haluzík, M. (CZ)
Železná, Blanka (UOCHB-X) RID, ORCID
Kiss, A. (SK)
Skurlová, M. (CZ)
Lacinová, Z. (CZ)
Jurcovicová, J. (CZ)Number of authors 7 Source Title Neuroimmunomodulation - ISSN 1021-7401
Roč. 16, č. 6 (2009), s. 377-384Number of pages 8 s. Language eng - English Country CH - Switzerland Keywords adjuvant arthritis ; anorexia ; leptin ; adiponectin Subject RIV CC - Organic Chemistry R&D Projects GA305/06/0427 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000270364500002 DOI 10.1159/000228912 Annotation Food intake is activated by hypothalamic orexigenic neuropeptide Y (NPY) controlled by leptin and ghrelin. Rat adjuvant arthritis (AA), and also human rheumatoid arthritis, is associated with cachexia. In our study, we evaluated NPY expression in hypothalamic arcuate nucleus (nARC) under AA-induced changes in leptin, ghrelin and adiponectin. Anorexia is centrally induced by IL-1β whose expression in the nARC was studied as well. In AA rats, decreased appetite, body mass, and epididymal fat positively correlated with reduced circulating and epididymal fat leptin and adiponectin. Plasma ghrelin was increased. In nARC, mRNA for leptin and ghrelin receptors, NPY, and IL-1beta were over-expressed in AA rats. However, circulating and spleen IL-1beta was unaltered in AA rats. During AA, despite of over-expression of orexigenic NPY in nARC, activated expression of IL-1beta in nARC kept AA-induced anorexia in progress. Lowered adiponectin might contribute to this anorexia. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2010
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