Number of the records: 1

Targed neural stem cell differentiation and related cell based therapy in spinal cord injury

SYSNO ASEP	0330776
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Targed neural stem cell differentiation and related cell based therapy in spinal cord injury
Author(s)	Skalníková, Helena (UZFG-Y)_{RID, ORCID} Vodička, Petr (UZFG-Y)_ORCID Halada, Petr (MBU-M)_{RID, ORCID} Maršala, M. (US) Motlík, Jan (UZFG-Y)_{RID, ORCID} Gadher, S. J. (CH) Kovářová, Hana (UZFG-Y)_{RID, ORCID}
Source Title	3rd Central and Eastern Proteomics Conference, 2009. - Budapest : Hungarian proteomic society, 2009 - ISBN 978-963-9319-99-8
Pages	s. 81-81
Number of pages	1 s.
Action	3rd Central and Eastern Proteomics Conference, 2009
Event date	06.10.2009-09.10.2009
VEvent location	Budapešť
Country	HU - Hungary
Event type	EUR
Language	eng - English
Country	HU - Hungary
Keywords	stem cells ; cell therapy ; spinal cord injury
Subject RIV	FH - Neurology
R&D Projects	1M0538 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
Annotation	Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2010

Number of the records: 1