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Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

SYSNO ASEP	0330753
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir
Author(s)	Grantz Šašková, Klára (UOCHB-X)_{RID, ORCID} Kožíšek, Milan (UOCHB-X)_{RID, ORCID} Řezáčová, Pavlína (UOCHB-X)_{RID, ORCID} Brynda, Jiří (UMG-J)_RID Yashina, T. (US) Kagan, R. M. (US) Konvalinka, Jan (UOCHB-X)_{RID, ORCID}
Number of authors	7
Source Title	Journal of Virology - ISSN 0022-538X Roč. 83, č. 17 (2009), s. 8810-8818
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	HIV-1 protease ; darunavir ; X-ray structural analysis ; protease inhibitor ; mutations
Subject RIV	CE - Biochemistry
R&D Projects	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000269122300048
DOI	10.1128/JVI.00451-09
Annotation	In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2010

Number of the records: 1