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Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats
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SYSNO ASEP 0330737 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats Title Vliv melatoninu, captoprilu, spironolaktonu a simvastatinu na krevní tlak a remodelaci levé komory srdeční u spontánně hypertenzních potkanů Author(s) Šimko, F. (SK)
Pecháňová, Olga (FGU-C)
Pelouch, Václav (FGU-C)
Krajčírovičová, K. (SK)
Müllerová, M. (SK)
Bednárová, K. (SK)
Adamcová, M. (CZ)
Paulis, L. (SK)Source Title Journal of Hypertension. - : Lippincott Williams & Wilkins - ISSN 0263-6352
Roč. 27, Suppl.6 (2009), S5-S10Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords cardiac hypertrophy ; fibrosis ; ventricular remodeling Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects GA305/09/0336 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000269549400002 DOI 10.1097/01.hjh.0000358830.95439.e8 Annotation Melatonin was shown to reduce blood pressure and oxidative load as well as to increase nitric oxide availability. It was investigated whether melatonin can reverse left ventricular remodeling in spontaneously hypertensive rats and to compare its protective effect with captopril, spironolactone, or simvastatin. It is concluded that although melatonin, in comparison with captopril, did not reverse left ventricle hypertrophy, it reversed left ventricular fibrosis due to its prominent antioxidative effect Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
Number of the records: 1