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Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind
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SYSNO ASEP 0330730 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind Title Chronická antioxidační léčba nedokáže ovlivnit hypertenzi: možné mechanismy Author(s) Pecháňová, Olga (FGU-C)
Šimko, F. (SK)Source Title Journal of Hypertension. - : Lippincott Williams & Wilkins - ISSN 0263-6352
Roč. 27, Suppl.6 (2009), S32-S36Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords endothelial dysfunction ; NADP(H) oxidase ; reactive oxygen species Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects GA305/08/0139 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000269549400007 DOI 10.1097/01.hjh.0000358835.25934.5e Annotation The elevated production of reactive oxygen species (ROS) is believed to play an important role in hypertension, but clinical studies on chronic antioxidant therapy of hypertension fail to confirm this hypothesis. Elevated ROS production in hypertension may also stimulate the activity of the antioxidant defense system and thus improve NO bioavailability. Prolonged antioxidant therapy may attenuate the beneficial regulatory effect of ROS Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
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