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Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension
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SYSNO ASEP 0330723 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension Title Srovnání účinků indapamidu a captoprilu na vývoj spontánní hypertenze Author(s) Vranková, S. (SK)
Jendeková, L. (SK)
Paulis, L. (SK)
Sládková, M. (SK)
Šimko, F. (SK)
Pecháňová, Olga (FGU-C)Source Title Journal of Hypertension. - : Lippincott Williams & Wilkins - ISSN 0263-6352
Roč. 27, Suppl.6 (2009), S42-S46Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords cardiac hypertrophy ; nitric oxide ; oxidant status Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery R&D Projects GA305/09/0336 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000269549400009 DOI 10.1097/01.hjh.0000358837.64052.0a Annotation The effects of indapamide, a thiazide-like diuretic, and captopril, an angiotensin-converting enzyme inhibitor, on spontaneous hypertension and the development of left ventricular hypertrophy (LVH), nitric oxide generation and oxidant status were investigated. Whereas captopril reduced LVH, indapamide enhanced NOS activity and decreased oxidative damage in the case of the combined treatment. The complex protective effects of the combined indapamide plus captopril treatment on hypertension are exerted via its effects on blood pressure, heart hypertrophy and vasorelaxation Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
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