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Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor
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SYSNO ASEP 0330473 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor Author(s) Valovičová, Z. (SK)
Marvanová, S. (CZ)
Mészárosová, M. (SK)
Strančíková, A. (SK)
Trilecová, L. (CZ)
Milcová, Alena (UEM-P)
Líbalová, Helena (UEM-P) RID
Vondráček, J. (CZ)
Machala, M. (CZ)
Topinka, Jan (UEM-P) RID, ORCID
Gábelová, A. (SK)Source Title Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 665, 1-2 (2009), s. 51-60Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords DNA adducts ; DNA strand breaks ; oxidative stress Subject RIV DN - Health Impact of the Environment Quality R&D Projects 2B08005 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) SP/1B3/8/08 GA MŽP - Ministry of Environment (MŽP) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000266690200008 DOI 10.1016/j.mrfmmm.2009.02.014 Annotation The qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 cells were demonstrated. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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