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The impact of air pollution on the level of micronuclei measured by automated image analysis
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SYSNO ASEP 0330452 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The impact of air pollution on the level of micronuclei measured by automated image analysis Author(s) Rössnerová, Andrea (UEM-P) RID
Špátová, Milada (UEM-P)
Rossner, P. (CZ)
Solanský, I. (CZ)
Šrám, Radim (UEM-P) RIDSource Title Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. - : Elsevier - ISSN 0027-5107
Roč. 669, 1-2 (2009), s. 42-47Number of pages 6 s. Language eng - English Country NL - Netherlands Keywords micronuclei ; binucleated cells ; automated image analysis Subject RIV DN - Health Impact of the Environment Quality R&D Projects 1QS500390506 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 2B06088 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 2B08005 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50390512 - UEM-P (2005-2011) UT WOS 000271065800007 DOI 10.1016/j.mrfmmm.2009.04.008 Annotation The results of a human biomonitoring study focused on the measurement of micronuclei (MN) by automated image analysis (MetaSystems Metafer 4) for assessing chromosomal damage as a result of environmental mutagen exposure. In a group of 56 city policemen from Prague the effect of exposure to carcinogenic polycyclic aromatic hydrocarbons (c-PAHs), volatile organic compounds and smoking on the frequency of MN was evaluated. The results demonstrate the ability of c-PAHs to increase MN frequency and confirm no differences between smokers and nonsmokers. It was confirmed that automatic image analysis of MN is a highly sensitive method for evaluating chromosomal damage by environmental pollution. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2010
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