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Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice
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SYSNO ASEP 0330364 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dynamics of Trace Element Concentration During Development and Excitotoxic Cell Death in the Cerebellum of Lurcher Mutant Mice Author(s) Bäurle, J. (DE)
Kučera, Jan (UJF-V) RID, ORCID, SAI
Frischmuth, S. (DE)
Lambertz, M. (DE)
Kranda, Karel (UJF-V)Source Title Brain Pathology - ISSN 1015-6305
Roč. 19, č. 4 (2009), s. 586-595Number of pages 10 s. Language eng - English Country US - United States Keywords apoptosis ; copper ; excitotoxicity Subject RIV BG - Nuclear, Atomic and Molecular Physics, Colliders R&D Projects GA309/09/1189 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000269575600004 DOI 10.1111/j.1750-3639.2008.00200.x Annotation Elevated concentrations of Zn, Cu and Fe, observed in biopsied or post-mortem tissue from diseased human brains, have often been considered as some of the major factors in the etiology of excitotoxic neuronal death but without any direct evidence for the causal role of metals. Although elevated metal concentrations that precede or coincide with the onset of neurodegeneration may provide such evidence, the dynamics of metal concentrations during excitotoxic cell death has never been established. Hence, we measured time-resolved Zn, Cu and Fe concentrations during the course of excitotoxic cell death in the Lurcher (Lc/+) mutant mouse with neutron activation analysis. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2010
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