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Detection of choline transporter-like 1 protein CTL1 in neuroblastoma × glioma cells and in the CNS, and its role in choline uptake

SYSNO ASEP	0330072
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Detection of choline transporter-like 1 protein CTL1 in neuroblastoma × glioma cells and in the CNS, and its role in choline uptake
Title	Detekce cholin transporter-like 1 proteinu (CTL1) v neuroblastomové × gliomové buněčné linii a v CNS a jeho úloha v cholinovém přenosu
Author(s)	Machová, Eva (FGU-C) O´Regan, S. (FR) Newcombe, J. (GB) Meunier, F. M. (FR) Prentice, J. (GB) Dove, R. (GB) Lisá, Věra (FGU-C) Doležal, Vladimír (FGU-C)_{RID, ORCID}
Source Title	Journal of Neurochemistry. - : Wiley - ISSN 0022-3042 Roč. 110, č. 4 (2009), s. 1297-1309
Number of pages	13 s.
Language	eng - English
Country	US - United States
Keywords	CTL1 ; choline ; cell growth
Subject RIV	ED - Physiology
R&D Projects	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA500110703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000268221500015
DOI	10.1111/j.1471-4159.2009.06218.x
Annotation	In this study the presence of CTL1 protein in NG108-15cells was confirmed using our antibody G103. Three different cognate small interfering RNAs were used to decrease CTL1 mRNA in NG108-15 cells, causing lowered CTL1 protein expression, choline uptake and cell growth. Our results support the concept that CTL1 protein is necessary for the high affinity choline transport which supplies choline for cell growth
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1