Epigenetics of multiple myeloma after treatment with cytostatics and gamma radiation

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SYSNO ASEP	0329797
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Epigenetics of multiple myeloma after treatment with cytostatics and gamma radiation
Title	Epigenetika mnohočetného myelomu po ovlivnění buněk cytostatiky a gama zářením
Author(s)	Krejčí, Jana (BFU-R)_{RID, ORCID} Harničarová, Andrea (BFU-R)_ORCID Štreitová, Denisa (BFU-R) Hájek, R. (CZ) Pour, L. (CZ) Kozubek, Stanislav (BFU-R)_RID Bártová, Eva (BFU-R)_ORCID
Source Title	Leukemia Research. - : Elsevier - ISSN 0145-2126 Roč. 33, č. 11 (2009), s. 1490-1498
Number of pages	9 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	multiple myeloma ; histone methylation ; histone acetylation
Subject RIV	BO - Biophysics
R&D Projects	LC06027 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000269870400013
DOI	10.1016/j.leukres.2009.03.016
Annotation	Cytostatics had a significant impact on histone modifications of the c-myc and CCND1 genes that are prognostically important for multiple myeloma (MM). Genome-wide analysis showed that cytostatics such as Melphalan increased H3K9 acetylation at some gene promoters in selected MM cell lines.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1