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Acetone, butanone, pentanone, hexanone and heptanone in the headspace of aqueous solution and urine studied by selected ion flow tube mass spectrometry
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SYSNO ASEP 0329749 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acetone, butanone, pentanone, hexanone and heptanone in the headspace of aqueous solution and urine studied by selected ion flow tube mass spectrometry Title Aceton, butanon, pentanon, hexanon a heptanon v headspace vodných roztoků a v moči studované pomocí hmotnostní spektrometrie v proudové trubici s vybranými ionty (SIFT-MS) Author(s) Wang, T. (GB)
Pysanenko, A. (GB)
Španěl, Patrik (UFCH-W) RID, ORCID
Smith, D. (GB)Source Title Rapid Communications in Mass Spectrometry. - : Wiley - ISSN 0951-4198
Roč. 23, č. 8 (2009), s. 1097-1104Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords trace gras-analysis ; breath analysis ; exhaled breath Subject RIV CF - Physical ; Theoretical Chemistry CEZ AV0Z40400503 - UFCH-W (2005-2011) UT WOS 000264944500001 DOI 10.1002/rcm.3963 Annotation Urine is commonly analysed in clinical practice by a variety of liquid-phase techniques to check for excessive ketone bodies, proteins and salts to name just a few compounds. However, little work has been carried out to measure the volatile compounds emitted by urine since these do not yet have an established role in clinical diagnosis. There is, however, a growing body of evidence that these volatile compounds can be indicators of adverse physiological conditions and disease and with the advent of sensitive gas-phase analytical methods they can be quickly quantified in urine headspace and potentially provide valuable support for clinical diagnosis. Thus, we are developing selected ion flow tube mass spectrometry, SIFT-MS, for the real-time analysis of urine headspace, ultimately to support rapid diagnosis in the clinical environment. In this paper we focus on volatile ketones in the headspace of aqueous solutions and urine donated by three healthy volunteers. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2010
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