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Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel

SYSNO ASEP	0329481
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel
Title	Esenciální úloha domnělé oblasti S6 vnitřního póru v procesech aktivace lidského TRPA1 kanálu
Author(s)	Benedikt, Jan (FGU-C) Samad, Abdul (FGU-C) Ettrich, Rüdiger (UEK-B)_{RID, ORCID, SAI} Teisinger, Jan (FGU-C)_RID Vlachová, Viktorie (FGU-C)_{RID, ORCID, SAI}
Source Title	Biochimica Et Biophysica Acta-Molecular Cell Research. - : Elsevier - ISSN 0167-4889 Roč. 1793, č. 7 (2009), s. 1279-1288
Number of pages	10 s.
Language	eng - English
Country	NL - Netherlands
Keywords	TRPA1 ; channel ; vanilloid receptor
Subject RIV	ED - Physiology
R&D Projects	GA305/06/0319 GA ČR - Czech Science Foundation (CSF)
	GA305/09/0081 GA ČR - Czech Science Foundation (CSF)
	GA303/07/0915 GA ČR - Czech Science Foundation (CSF)
	IAA600110701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	1M0517 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
	AV0Z60870520 - UEK-B (2005-2011)
UT WOS	000267772400017
DOI	10.1016/j.bbamcr.2009.04.014
Annotation	In this study we used scanning mutagenesis of the residues within the putative inner pore S6 region of TRPA1 channel with the aim of understanding the process of TRPA1 activation. We identify residues proline 949, asparagine 954 and glycine–(X)3-glycine motif as structural determinants of TRPA1 activation and deactivation and these findings contribute to our better understanding of molecular mechanisms of pain sensation
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1