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Dissection of Chromosome 18 Blood Pressure and Salt-Sensitivity Quantitative Trait Loci in the Spontaneously Hypertensive Rat

SYSNO ASEP	0329310
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Dissection of Chromosome 18 Blood Pressure and Salt-Sensitivity Quantitative Trait Loci in the Spontaneously Hypertensive Rat
Title	Analýza genetických determinant na chromozomu 18 asociovaných s krevním tlakem a citlivostí k soli u spontánně hypertenzních potkanů
Author(s)	Johnson, M.D. (GB) He, L. (GB) Herman, D. (US) Wakimoto, H. (US) Wallace, C. A. (GB) Zídek, Václav (FGU-C)_RID Mlejnek, Petr (FGU-C)_{RID, ORCID} Musilová, Alena (FGU-C) Šimáková, Miroslava (FGU-C)_{RID, ORCID} Vorlíček, Jaroslav (FGU-C) Křen, Vladimír (FGU-C) Vyklický, O. (CZ) Qi, N.R. (US) Wang, J. (US) Seidman, Ch. E. (US) Seidman, J. (US) Kurtz, T. W. (US) Aitman, T. J. (GB) Pravenec, Michal (FGU-C)_{RID, ORCID}
Source Title	Hypertension. - : Lippincott Williams & Wilkins - ISSN 0194-911X Roč. 54, č. 3 (2009), s. 639-645
Number of pages	7 s.
Language	eng - English
Country	US - United States
Keywords	spontaneously hypertensive rat ; salt sensitivity ; gene
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	1M0520 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	1P05ME791 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA301/08/0166 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000269089100037
DOI	10.1161/HYPERTENSIONAHA.108.126664
Annotation	In this study, we genetically isolated and analyzed the genes within the salt sensitivity and hypertension QTLs on spontaneously hypertensive rat (SHR) SHR chromosome 18, by developing and characterising a series of congenic strains in which we transferred the corresponding region of chromosome 18 from the normotensive and salt resistant Brown Norway (BN) rat onto the genetic background of the salt sensitive SHR/Ola strain
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1