Number of the records: 1

Porcine neuronal models that recapitulate HD pathogenesis in vitro

SYSNO ASEP	0329308
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	Porcine neuronal models that recapitulate HD pathogenesis in vitro
Author(s)	Hruška-Plocháň, Marian (UZFG-Y)_RID Vodička, Petr (UZFG-Y)_ORCID Lacková, Monika (UZFG-Y)_RID Usvald, Dušan (UZFG-Y) Juhás, Štefan (UZFG-Y)_{RID, ORCID} Hrdličková, R. (CZ) Miyanohara, A. (US) Maršala, M. (US) Motlík, Jan (UZFG-Y)_{RID, ORCID}
Source Title	IV. Meeting on the molecular mechanisms of neurodegeneration , P 50. - Milano : Keyword Europa, 2009
Pages	s. 32-32
Number of pages	1 s.
Action	IV. Meeting on the molecular mechanisms of neurodegeneration
Event date	08.05.2009-10.05.2009
VEvent location	Miláno
Country	IT - Italy
Event type	WRD
Language	eng - English
Country	IT - Italy
Keywords	Huntington disease ; porcine neuronal model
Subject RIV	FH - Neurology
R&D Projects	1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z50450515 - UZFG-Y (2005-2011)
Annotation	Huntington disease is a fatal dominantly inherited neurodegenerative disease caused by the expansion of polyCAG stretch in gene coding ubiquitous huntingtin protein(htt). Selectively striatal neuronal loss followed by degemeration of cortex and other brain and non. neuronal regions occur in HD, but the function of mutated htt is not yet fully defined. The aim of this study is to develop porcine in vitro neuronal model that recapitulates major pathogenic steps in HD and would be much easily accessible than human cells and much closer to those primate origin that the rodent one
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2010

Number of the records: 1