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Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector
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SYSNO ASEP 0329291 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector Author(s) Šolínová, Veronika (UOCHB-X) RID, ORCID
Kašička, Václav (UOCHB-X) RID, ORCID
Sázelová, Petra (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)Number of authors 4 Source Title Electrophoresis. - : Wiley - ISSN 0173-0835
Roč. 30, č. 12 (2009), s. 2245-2254Number of pages 10 s. Language eng - English Country DE - Germany Keywords antiviral drugs ; capillary electrophoresis ; enantioseparation Subject RIV CB - Analytical Chemistry, Separation R&D Projects GA203/06/1044 GA ČR - Czech Science Foundation (CSF) GA203/08/1428 GA ČR - Czech Science Foundation (CSF) 1QS400550501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000268270400025 DOI 10.1002/elps.200800790 Annotation A new capillary electrophoretic method has been developed for chiral analysis of an important anti-AIDS drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine ((R)-PMPA, tenofovir), and six related antiviral acyclic nucleoside phosphonates using beta cyclodextrin (beta CD) as a chiral selector. Complete separations of (R,S)-enantiomers of PMPA with very good resolution (Rs = 1.50 – 3.64) were achieved within a short time (4 – 15 min) in 20 – 50 mM sodium borate or sodium tetraborate BGEs, pH 10.0, at 20 mg/mL concentration of beta CD. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2010
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