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Substitution of adenine for guanine in the quadruplex-forming human telomere DNA sequence G3(T2AG3)3
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SYSNO ASEP 0329204 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Substitution of adenine for guanine in the quadruplex-forming human telomere DNA sequence G3(T2AG3)3 Title Substituce adeninu za guanin v quadruplex tvořící lidské telomerové DNA sekvenci Author(s) Tomaško, Martin (BFU-R) RID
Vorlíčková, Michaela (BFU-R) RID, ORCID
Sagi, J. (US)Source Title Biochimie. - : Elsevier - ISSN 0300-9084
Roč. 91, č. 2 (2009), s. 171-179Number of pages 9 s. Language eng - English Country FR - France Keywords human telomere DNA ; guanine quadruplex structure ; CD spectroscopy Subject RIV BO - Biophysics R&D Projects GA204/07/0057 GA ČR - Czech Science Foundation (CSF) IAA100040701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000263813300002 DOI 10.1016/j.biochi.2008.07.012 Annotation We have studied the formation and structural properties of quadruplexes of the human telomeric DNA sequence G3(T2AG3)3 and related sequences in which each guanine base was replaced by an adenine base. None of these single base substitutions hindered the formation of antiparallel quadruplexes in NaCl and KCl solutions. Effect of substitution did differ, however, depending on the position of the substituted base. The A-for-G substitution in the middle quartet of the antiparallel basket scaffold led to the most distorted and least stable structures and these sequences preferred to form biomolecular quadruplexes. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
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