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Reduced inducibility of SOCS3 by interferon gamma associates with higher resistance of human breast cancer lines as compared to normal mammary epithelial cells
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SYSNO ASEP 0329203 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Reduced inducibility of SOCS3 by interferon gamma associates with higher resistance of human breast cancer lines as compared to normal mammary epithelial cells Title Nádorové linie lidského nádoru mléčné žlázy vykazují vyšší resistenci vůči interferonu gama a redukovanou inducibilitu SOCS3 oproti normálním epitheliálním buňkám Author(s) Součková, K. (CZ)
Kovařík, Aleš (BFU-R) RID, ORCID
Dušek, L. (CZ)
Humpolíková Adámková, L. (CZ)
Lauerová, L. (CZ)
Krejčí, E. (CZ)
Matoušková, E. (CZ)
Buršíková, E. (CZ)
Fojtová, M. (CZ)
Kovařík, J. (CZ)Source Title Neoplasma - ISSN 0028-2685
Roč. 56, č. 5 (2009), s. 379-386Number of pages 8 s. Language eng - English Country SK - Slovakia Keywords breast cancer carcinoma ; interferons ; SOCS3 gene induction Subject RIV BO - Biophysics CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000269333200002 DOI 10.4149/neo_2009_05_379 Annotation In this work we have analysed inducibility of SOCS3 gene by interferon gamma in several human breast cancer lines and normal epithelial cells. We found that reduced inducibility of SOCS3 observed in most malignant cells was correlated with increased resistance to the cytotoxic effect of interferon gamma. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
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