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Quadruplex-forming properties of FRAXA (CGG) repeats interrupted by (AGG) triplets

SYSNO ASEP	0329202
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Quadruplex-forming properties of FRAXA (CGG) repeats interrupted by (AGG) triplets
Title	Tvorba kvadruplexů repeticemi (CGG), spojenými se syndromem FRAXA, a jejich analogy přerušenými AGG triplety
Author(s)	Renčiuk, Daniel (BFU-R)_{RID, ORCID} Zemánek, Michal (BFU-R) Kejnovská, Iva (BFU-R)_{RID, ORCID} Vorlíčková, Michaela (BFU-R)_{RID, ORCID}
Source Title	Biochimie. - : Elsevier - ISSN 0300-9084 Roč. 91, č. 3 (2009), s. 416-422
Number of pages	7 s.
Language	eng - English
Country	FR - France
Keywords	fragile X-chromosome ; quadruplex ; CD spectroscopy
Subject RIV	BO - Biophysics
R&D Projects	GA204/07/0057 GA ČR - Czech Science Foundation (CSF)
	IAA100040701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000264433400012
DOI	10.1016/j.biochi.2008.10.012
Annotation	In this work we studied the ability of microsatellite (CGG)n, releated to FRAXA syndrome, to form guanine quadruplexes. We show that this microsatellite do not form quadruplex easily in an aqueous solution, the presence of AGG triplets, typical for healthy individuals, facilitates the quadruplex formation and that the presence of ethanol as a molecular crowding compound leads to the stabilization even of (CGG)16.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1