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Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
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SYSNO ASEP 0329066 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase Author(s) Hocková, Dana (UOCHB-X) RID, ORCID
Holý, Antonín (UOCHB-X)
Masojídková, Milena (UOCHB-X)
Keough, D. T. (AU)
de Jersey, J. (AU)
Guddat, L. W. (AU)Number of authors 6 Source Title Bioorganic & Medicinal Chemistry. - : Elsevier - ISSN 0968-0896
Roč. 17, č. 17 (2009), s. 6218-6232Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords acyclic nucleoside phosphonates ; drug design ; phosphoribosyltransferase ; enzyme inhibitors ; purine salvage pathway Subject RIV CC - Organic Chemistry R&D Projects 1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1QS400550501 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000269029100009 DOI 10.1016/j.bmc.2009.07.044 Annotation Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) is the key enzyme in purine metabolism of the malarial parasite Plasmodium falciparum (Pf). Two series of novel branched ANPs derived from 9-[2-(2-phosphonoethoxy)ethyl]purines were synthesized to investigate their inhibition of Pf and human 6-oxopurine phosphoribosyltransferase. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2010
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