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Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom

SYSNO ASEP	0328907
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom
Author(s)	Dračínský, Martin (UOCHB-X)_{RID, ORCID} Holý, Antonín (UOCHB-X) Jansa, Petr (UOCHB-X)_RID Kovačková, Soňa (UOCHB-X) Buděšínský, Miloš (UOCHB-X)_{RID, ORCID}
Number of authors	5
Source Title	European Journal of Organic Chemistry - ISSN 1434-193X -, č. 24 (2009), s. 4117-4122
Number of pages	6 s.
Language	eng - English
Country	DE - Germany
Keywords	isotopes ; NMR spectroscopy ; pyrimidines
Subject RIV	CC - Organic Chemistry
R&D Projects	KJB400550903 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000269221800012
DOI	10.1002/ejoc.200900529
Annotation	Anotace angl: The proton to deuterium exchange reaction of hydrogen atom in position 5 of the fifteen pyrimidine derivatives was studied. The exchange proceeds under both acidic and alkaline conditions: under acidic conditions, the mechanism involves protonation at position 5 (forming a s-complex), whereas under alkaline conditions, the exchange is caused mainly by the equilibrium of the tautomers involving one tautomer with a sp3 -hybridised carbon atom in position 5.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2010

Number of the records: 1