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Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption
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SYSNO ASEP 0328844 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Supported lipid bilayer on nanocrystalline diamond: dual optical and field-effect sensor for membrane disruption Title Lipidní dvojvrstvy na nanokrystalickém diamantu: Senzor kvality mambrány Author(s) Ang, P.K. (SG)
Loh, K.P. (SG)
Wohland, T. (SG)
Nesládek, Miloš (FZU-D)
Van Hove, E. (FR)Number of authors 5 Source Title Advanced Functional Materials - ISSN 1616-301X
Roč. 19, č. 1 (2009), s. 109-116Number of pages 8 s. Language eng - English Country DE - Germany Keywords nanocrystalline diamond ; biocompatibility ; supported lipid bilayers ; biosensors ; solution gate field effect transistor Subject RIV BM - Solid Matter Physics ; Magnetism CEZ AV0Z10100520 - FZU-D (2005-2011) UT WOS 000262584800010 DOI 10.1002/adfm.200800770 Annotation It is demonstrated that a good biomimetic model lipid membrane with dynamic fluidity can be established on optically transparent nanocrystalline diamond (OTND) with surface roughness below 10nm. Maigainin II, an antimicrobial peptide, is chosen to investigate the permeation of artificial bacterial membranes constructed on OTND. Due to the unique combination of optical transparency and highly sensitive surface conducting channel, intrinsic OTND affords the possibility of dual-mode sensing based on optical and field effect properties. This opens up new possibilities for making integrated biomolecule–semiconductor microdevices, or sensors where the binding of biomolecules can be tracked using confocal microscopy whilst the associated changes in charge density during membrane perforation can be tracked using the space charge effect in the semiconductor. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2010
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