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Preparation and preliminary biological screening of cholic acid–juvenoid conjugates
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SYSNO ASEP 0328621 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Preparation and preliminary biological screening of cholic acid–juvenoid conjugates Title Příprava a předběžné biologické testování konjugátů cholové kyseliny s juvenoidy Author(s) Jurček, Ondřej (UEB-Q)
Wimmer, Zdeněk (UEB-Q) RID, ORCID
Svobodová, Hana (UEB-Q)
Bennettová, Blanka (BC-A)
Kolehmainen, E. (FI)
Drašar, P. (CZ)Source Title Steroids. - : Elsevier - ISSN 0039-128X
Roč. 74, č. 9 (2009), s. 779-785Number of pages 7 s. Language eng - English Country US - United States Keywords Neobellieria bullata ; Cholic acid ; Juvenoid Subject RIV GM - Food Processing R&D Projects 2B06024 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50380511 - UEB-Q (2005-2011) AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000268129000012 DOI 10.1016/j.steroids.2009.04.006 Annotation Steroidal compounds have been utilized as carriers and for modification of physico-chemical Properties of model biologically active secondary alcohols - juvenoids. Juvenoids are juvenile hormone analogues - environmentally safe insecticides, possessing significant biological activity towards different arthropods groups in focus on insect pest species. Structure modification of juvenoids plays important role to control the rate of liberation and decomposition of juvenoid in digestive system and can also play important role in the mode of action towards selected insect. This study presents an approach to the synthesis of steroidal monomers and dimers carrying one and two molecules of a juvenoid in their structures. The prepared compounds were tested for their inhibition activity on reproduction of the blowfly Neobellieria (Sarcophaga) bullata. These steroid-juvenoid conjugates showed promising possibilities in synthesis of new unique biochemical insecticides. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2010
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