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Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors

SYSNO ASEP	0328588
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors
Title	Funkční úloha aromatických reziduí v první transmembránové doméně P2X receptorů
Author(s)	Jindřichová, Marie (FGU-C)_RID Vávra, Vojtěch (FGU-C)_RID Obšil, Tomáš (FGU-C)_{RID, ORCID} Stojilkovic, S. S. (US) Zemková, Hana (FGU-C)_{RID, ORCID}
Source Title	Journal of Neurochemistry. - : Wiley - ISSN 0022-3042 Roč. 109, č. 3 (2009), s. 923-934
Number of pages	12 s.
Language	eng - English
Country	US - United States
Keywords	purinergic receptors ; gating ; transmembrane domain
Subject RIV	FH - Neurology
R&D Projects	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	IAA5011408 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IAA500110702 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	IAA500110910 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000265013700022
DOI	10.1111/j.1471-4159.2009.06021.x
Annotation	Purinergic P2X receptors, activated by extracellular ATP, play a role in pain sensation and immune response. We studied the structure of the first transmembrane domains of the P2X4 receptor, and functional role of conserved tyrosine and other aromatic amino acids in five subtypes of P2X family. We found that aromatic residues contribute to regulation of agonist binding at P2X1, P2X2, P2X3, P2X4 and P2X7 receptors, and play an important role in channel gating
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1