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The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level
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SYSNO ASEP 0328561 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level Title Úloha TRPV1 endogenního agonisty N-oleoyldopaminu v modulaci nociceptivní signalizace na míšní úrovni Author(s) Špicarová, Diana (FGU-C) RID, ORCID
Paleček, Jiří (FGU-C) RID, ORCIDSource Title Journal of Neurophysiology - ISSN 0022-3077
Roč. 102, č. 1 (2009), s. 234-243Number of pages 10 s. Language eng - English Country US - United States Keywords pain ; TRPV1 ; spinal cord Subject RIV FH - Neurology CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000267446000023 DOI https://doi.org/10.1152/jn.00024.2009 Annotation OLDA application in acute spinal cord slices leads to significant increase of AMPA mediated mEPSC frequency in high concentration. After PKC activation or under pathological conditions only low concentration is needed. Presynaptic spinal cord TRPV1 receptors have a significant modulatory role in nociceptive signalling and may be activated by low concentrations of endogenous agonists like OLDA under pathological conditions Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2010
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