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The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats

SYSNO ASEP	0328539
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats
Title	Vliv agonistů/antagonistů D1 receptorů na lokomoční aktivitu, senzorimotorický gating a kognitivní funkce u lab. potkanů po aplikaci dizocilpinu
Author(s)	Bubeníková-Valešová, V. (CZ) Svoboda, Jan (FGU-C)_{RID, ORCID} Horáček, J. (CZ) Valeš, Karel (FGU-C)_{RID, ORCID, SAI}
Source Title	International Journal of Neuropsychopharmacology - ISSN 1461-1457 Roč. 12, č. 7 (2009), s. 873-883
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	animal model ; cognitive function ; D1 receptor
Subject RIV	FH - Neurology
R&D Projects	1M0517 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA309/07/0341 GA ČR - Czech Science Foundation (CSF)
	NR9178 GA MZd - Ministry of Health (MZ)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000268624700002
DOI	10.1017/S1461145708009851
Annotation	Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. We investigate the systemic effect of a D1R agonist (A77636) and antagonist (SCH 23390) on hyperlocomotor activity and cognitive deficit induced by an NMDA receptor antagonist (MK-801). Administration of the D1R antagonist had no effect on cognitive function, but decreased hyperlocomotion induced by MK-801. Thus, based on our results, over-activation of D1Rs may exacerbate psychotic symptoms in patients with schizophrenia
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1