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Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells
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SYSNO ASEP 0328368 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells Author(s) Kuželová, K. (CZ)
Grebeňová, D. (CZ)
Pluskalová, M. (CZ)
Kavan, Daniel (MBU-M) RID, ORCID
Halada, Petr (MBU-M) RID, ORCID
Hrkal, Z. (CZ)Source Title Journal of Cellular Biochemistry. - : Wiley - ISSN 0730-2312
Roč. 106, č. 4 (2009), s. 673-681Number of pages 9 s. Language eng - English Country US - United States Keywords k562 ; apoptosis ; 14-3-3 Subject RIV CE - Biochemistry R&D Projects NR9243 GA MZd - Ministry of Health (MZ) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000264456300021 DOI 10.1002/jcb.22061 Annotation The proteins of 14-3-3 family are substantially involved in the regulation of many biological processes including the apoptosis. We studied the changes in the expression of five 14-3-3 isoforms during the apoptosis of JURL-MK1 and K562 cells. The expression level of all these proteins markedly decreased in relation with the apoptosis progression and all isoforms underwent truncation, which probably corresponds to the removal of several C-terminal amino acids. The observed 14-3-3 modifications were partially blocked by caspase-3 inhibition Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
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