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Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity
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SYSNO ASEP 0328344 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity Title Enzymová příprava acylovaných derivátů silybinu v organických a iontových tekutých médiích a hodnocení jejich antitumorické proliferativní aktivity Author(s) Theodosiou, E. (GR)
Katsoura, M. H. (GR)
Loutrari, H. (GR)
Purchartová, Kateřina (MBU-M) RID
Křen, Vladimír (MBU-M) RID, ORCID
Kolisis, F. N. (GR)
Stamatis, H. (GR)Source Title Biocatalysis and Biotransformation - ISSN 1024-2422
Roč. 27, č. 3 (2009), s. 161-169Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords silybin ; lipase ; ionic liquids Subject RIV CE - Biochemistry R&D Projects ME 922 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50200510 - MBU-M (2005-2011) UT WOS 000268032500001 DOI 10.1080/10242420902937777 Annotation Biocatalytic preparation of acylated derivatives of silybin using several acyl donors (free fatty acids or their esters), catalyzed by immobilized Candida antarctica lipase B, was performed in various organic solvents as well as in imidazolium-based ionic liquids containing either BF-4 or PF-6 anions. Total conversion of silybin was achieved in acetone using short-chain acyl donors (vinyl butanoate) at a 10:1 molar ratio of acyl donor to silybin. The enzymatic process in ionic liquids depended strongly on the alkyl chain length of the cation as well the anion used. Higher conversion yields (up to 75.8 percent) and reaction rates (up to 0.31 mmol h-1 g-1 biocatalyst) were obtained in the BF-4 as compared with PF-6 - containing ionic liquids Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
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