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Analysis of Energy Stabilization inside the Hydrophobic Core of Rubredoxin

SYSNO ASEP	0327972
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Analysis of Energy Stabilization inside the Hydrophobic Core of Rubredoxin
Author(s)	Berka, Karel (UOCHB-X) Hobza, Pavel (UOCHB-X)_{RID, ORCID} Vondrášek, Jiří (UOCHB-X)_{RID, ORCID}
Number of authors	3
Source Title	ChemPhysChem. - : Wiley - ISSN 1439-4235 Roč. 10, č. 3 (2009), s. 543-548
Number of pages	6 s.
Language	eng - English
Country	DE - Germany
Keywords	hydrophobic core ; protein stability ; SAPT method
Subject RIV	CF - Physical ; Theoretical Chemistry
R&D Projects	GA203/05/0009 GA ČR - Czech Science Foundation (CSF)
	GA203/06/1727 GA ČR - Czech Science Foundation (CSF)
	GD203/05/H001 GA ČR - Czech Science Foundation (CSF)
	IAA400550510 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LC512 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
UT WOS	000264229900014
DOI	10.1002/cphc.200800401
Annotation	The hydrophobic core of globular proteins is responsible for major stabilization of the protein tertiary structure. The prevailing amino-acid residues in the core are of aliphatic or aromatic character, and therefore, the core in a folded protein structure is mostly stabilized by noncovalent interactions of van der Waals origin between the amino-acid side chains. Herein, we present a theoretical analysis of the interaction energy between the amino acids of the hydrophobic core of the small globular protein rubredoxin (Rd) based on the symmetry-adapted perturbation theory (SAPT) method.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2010

Number of the records: 1