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Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats

SYSNO ASEP	0327874
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats
Author(s)	Folbergrová, Jaroslava (FGU-C)_RID Druga, Rastislav (FGU-C)_{RID, ORCID, SAI} Tsenov, Grygoriy (FGU-C)_{RID, ORCID} Haugvicová, Renata (FGU-C) Otáhal, Jakub (FGU-C)_{RID, ORCID, SAI}
Source Title	Brain Research. - : Elsevier - ISSN 0006-8993 Roč. 1273, - (2009), s. 144-154
Number of pages	11 s.
Language	eng - English
Country	NL - Netherlands
Keywords	DL-homocysteic acid-induced seizures ; posttreatment with 2R ; 4R-APDC ; partial protection
Subject RIV	FH - Neurology
R&D Projects	GA309/05/2015 GA ČR - Czech Science Foundation (CSF)
	GA309/08/0292 GA ČR - Czech Science Foundation (CSF)
	GA304/07/1137 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000267516600016
DOI	10.1016/j.brainres.2009.03.045
Annotation	Anticonvulsant and neuroprotective effect of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate, agonist for group II metabotropic glutamate receptors, was substantially reduced when given after the onset of seizures induced in immature rats by homocysteic acid. The severity of seizures, changes of brain energy metabolites and neuronal damage of hippocampus and thalamus were influenced only partially
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1