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Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery

SYSNO ASEP	0327497
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery
Title	Monocytická diferenciace leukemických buněk HL-60 indukovaná společným působením TNF-alfa a MK886 vyžaduje aktivaci pro-apoptotických mechanizmů
Author(s)	Procházková, Jiřina (BFU-R)_{RID, ORCID} Stixová, Lenka (BFU-R)_{RID, ORCID} Souček, Karel (BFU-R)_{RID, ORCID} Hofmanová, Jiřina (BFU-R)_{RID, ORCID} Kozubík, Alois (BFU-R)_{RID, ORCID}
Source Title	European Journal of Haematology - ISSN 0902-4441 Roč. 83, č. 1 (2009), s. 35-47
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	caspases ; MAPK ; MK886
Subject RIV	BO - Biophysics
R&D Projects	GP524/06/P345 GA ČR - Czech Science Foundation (CSF)
	1QS500040507 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
	AV0Z50040702 - BFU-R (2007-2013)
UT WOS	000266875000004
DOI	10.1111/j.1600-0609.2009.01240.x
Annotation	Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 is accompanied by activation of pro-apoptotic kinases p38 and JNK and caspases 8 and 9. Pharmacologic inhibition of those processes resulted in a decreased amount of differentiated cells, which illustrates the importance of those signaling pathways in monocytic differentiation of leukemic cells.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2010

Number of the records: 1