Number of the records: 1

Alfa-Galactosidases and their applications in biotransformations

SYSNO ASEP	0327476
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Alfa-Galactosidases and their applications in biotransformations
Title	Alfa-Galaktosidasy a jejich aplikace v biotransformacích
Author(s)	Weignerová, Lenka (MBU-M)_RID Simerská, Pavla (MBU-M) Křen, Vladimír (MBU-M)_{RID, ORCID}
Source Title	Biocatalysis and Biotransformation - ISSN 1024-2422 Roč. 27, č. 2 (2009), s. 79-89
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	-Galactosidase ; enzyme ; transglycosylation
Subject RIV	EI - Biotechnology ; Bionics
R&D Projects	LC06010 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA203/05/0172 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50200510 - MBU-M (2005-2011)
UT WOS	000263717000001
DOI	10.1080/10242420802583416
Annotation	a-D-Galactosidases (a-D-galactoside galactohydrolase, E.C. 3.2.1.22) are exoglycosidases, which in vivo catalyze the hydrolysis of simple and complex oligo- and polysaccharides containing terminal a-D-galactosyl groups. A number of industrial applications of a-D- galactosidases are known, mainly in the sugar industry, pulp and paper industry or medicine. Although a-D-galactosidases occur in all living systems, microbial and possibly plant enzymes are preferred for practical applications. The regioselectivity of glycosidases is somewhat poor. Selective protection of oligosaccharides and development of new modified donors/acceptors is a promising method to overcome this problem. Genetic engineering has enabled the creation of glycosynthases from the hydrolytic glycosidases, which are highly complementary to glycosyltransferases. The present review summarizes recent advances in the application of a-D-galactosidases in synthetic and biotransformation applications
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2010

Number of the records: 1