Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I

Plecitá-Hlavatá, Lydie; Ježek, Jan; Ježek, Petr

doi:https://dx.doi.org/10.1016/j.biocel.2009.02.015

Number of the records: 1

Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I

1.

SYSNO ASEP	0327385
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I
Title	Pro-oxidativní, do mitochondrií cílený Ubichinon MitoQ10 působí jako anti-oxidant, když je zpomalený elektronový transport nebo pumpování protonů na Komplexu I
Author(s)	Plecitá-Hlavatá, Lydie (FGU-C)_{RID, ORCID} Ježek, Jan (FGU-C)_{RID, ORCID} Ježek, Petr (FGU-C)_{RID, ORCID}
Source Title	International Journal of Biochemistry and Cell Biology. - : Elsevier - ISSN 1357-2725 Roč. 41, 8-9 (2009), s. 1697-1707
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	oxidative stress ; MitoQ10 ; Complex I
Subject RIV	CE - Biochemistry
R&D Projects	NR7917 GA MZd - Ministry of Health (MZ)
	GA303/07/0105 GA ČR - Czech Science Foundation (CSF)
	GP303/05/P100 GA ČR - Czech Science Foundation (CSF)
	IAA500110701 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
CEZ	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000266755400008
DOI	10.1016/j.biocel.2009.02.015
Annotation	To elucidate pro- and anti-oxidant action of MitoQ10, we studied its effects on HEP-G2 cell respiration, mitochondrial network morphology, and rates of superoxide release (above that neutralized by superoxide dismutase) to the mitochondrial matrix (Jm). Results suggest that MitoQ10 accepts electron prior to the rotenone-bound Q-site, and the Complex II reverse mode oxidizes MitoQ10H2 to regenerate MitoQ10. Consequently, MitoQ10 has a pro-oxidant role in intact cells, whereas it serves as an antioxidant when Complex I-derived superoxide generation is already elevated due to electron flow retardation
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2010

Number of the records: 1