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The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity
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SYSNO ASEP 0327220 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity Title Efekt H1-antihistaminik na produkci oxidu dusnatého buňkami RAW 264.7 s ohledem na jejich lipofilicitu Author(s) Králová, Jana (BFU-R)
Račková, L. (SK)
Pekarová, Michaela (BFU-R) RID
Kubala, Lukáš (BFU-R) RID, ORCID
Nosál, R. (SK)
Jančinová, V. (SK)
Číž, Milan (BFU-R) RID, ORCID
Lojek, Antonín (BFU-R) RIDSource Title International Immunopharmacology. - : Elsevier - ISSN 1567-5769
Roč. 9, 7-8 (2009), s. 990-995Number of pages 6 s. Language eng - English Country NL - Netherlands Keywords H1-antihistamines ; nitric oxide ; inducible nitric oxide synthase Subject RIV BO - Biophysics R&D Projects 1QS500040507 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) GA525/06/1196 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000267444800026 DOI 10.1016/j.intimp.2009.04.005 Annotation In this study we demonstrated that the structural properties of H1-antihistamines, particularly lipophilicity, significantly affect the biological activity of macrophages. These drugs are able to modulate NO production in vitro by macrophage cell line RAW 264.7 stimulated by LPS. The modulation shown in this study could be caused by the downregulation of iNOS protein expression or by iNOS enzyme activity. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
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