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- Hydroxylated Anthraquinones Produced by Geosmithia species
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SYSNO ASEP 0327075 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title - Hydroxylated Anthraquinones Produced by Geosmithia species Author(s) Stodůlková, Eva (MBU-M) ORCID
Kolařík, Miroslav (MBU-M) RID, ORCID
Křesinová, Zdena (MBU-M) RID
Kuzma, Marek (MBU-M) ORCID, RID
Šulc, Miroslav (MBU-M) RID, ORCID
Man, Petr (MBU-M) RID, ORCID
Novák, Petr (MBU-M) RID, ORCID
Maršík, Petr (UEB-Q) RID, ORCID
Landa, Přemysl (UEB-Q) RID, ORCID
Olšovská, Jana (MBU-M)
Chudíčková, Milada (MBU-M)
Pažoutová, Sylvie (MBU-M)
Černý, J. (CZ)
Bella, J. (GB)
Flieger, Miroslav (MBU-M) ORCIDSource Title Folia Microbiologica. - : Springer - ISSN 0015-5632
Roč. 54, č. 3 (2009), s. 179-187Number of pages 9 s. Language eng - English Country CZ - Czech Republic Keywords hydroxylated anthraquinones ; staphylococcus aureus ; mammalian cell lines Subject RIV EE - Microbiology, Virology R&D Projects KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC07017 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) 1M0506 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GP203/05/P575 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50200510 - MBU-M (2005-2011) AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000268573600001 DOI - Annotation Hydroxylated anthraquinones (yellow, orange, and red pigments), were found to be the most abundant compounds produced into the medium during the submerged cultivation. Three main compounds were identified as 1,3,6,8-tetrahydroxyanthraquinone (1), rhodolamprometrin (1-acetyl-2,4,5,7-tetrahydroxyanthraquinone; 2), and 1-acetyl-2,4,5,7,8-pentahydroxyanthraquinone (3). Compounds 2 and 3 (representing the majority of produced metabolites) inhibited the growth of G plus minus bacteria Staphylococcus aureus and Bacillus subtilis with minimum inhibitory concentration of 64–512 g/mL. Anti-inflammatory activity detected as inhibition of cyclooxygenase-2 was found only for compound 3 at 1 and 10 g/mL. Compound 2 interfered with the morphology, compound 3 with cell-cycle dynamics of adherent mammalian cell lines Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2010
Number of the records: 1