Number of the records: 1
IrAM—An .alpha..sub.2./sub.-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes
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SYSNO ASEP 0327045 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title IrAM—An .alpha.2-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes Author(s) Burešová, Veronika (BC-A) RID, ORCID
Hajdušek, Ondřej (BC-A) RID, ORCID
Franta, Zdeněk (BC-A)
Sojka, Daniel (BC-A) RID, ORCID
Kopáček, Petr (BC-A) RID, ORCIDSource Title Developmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X
Roč. 33, č. 4 (2009), s. 489-198Number of pages 10 s. Language eng - English Country GB - United Kingdom Keywords α2-macroglobulin ; tick ; phagocytosis Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA600220603 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06009 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z60220518 - PAU-O, BC-A (2005-2011) UT WOS 000263781100009 DOI 10.1016/j.dci.2008.09.011 Annotation We have cloned, sequenced and characterized an macromolecular protease inhibitor of α2-macroglobulin family from the hard tick Ixodes ricinus named IrAM. Using the tool of RNA interference we have demonstrated that IrAM is an important constituent of tick innate immunity since it is involved in the phagocytosis of the pathogen Chryseobacterium indologenes by tick hemocytes. This is the first evidence showing that a cellular immune response in invertebrates is linked with interaction of an plasma α2-macroglobulin with protease derived from invading pathogen. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2010
Number of the records: 1