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2,2', 4,4',5,5'-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells
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SYSNO ASEP 0327032 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title 2,2', 4,4',5,5'-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells Title 2,2', 4,4',5,5'-Hexachlorobiphenyl (PCB 153) způsobuje degradaci proteinů tvořících adherentní spoje a inhibuje v jaterních epiteliálních buňkách transkripci kontrolovanou beta-kateninem Author(s) Šimečková, P. (CZ)
Vondráček, J. (CZ)
Procházková, J. (CZ)
Kozubík, Alois (BFU-R) RID, ORCID
Krčmář, P. (CZ)
Machala, M. (CZ)Source Title Toxicology. - : Elsevier - ISSN 0300-483X
Roč. 260, 1-3 (2009), s. 104-111Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords polychlorinated biphenyls ; E-cadherin ; beta-catenin Subject RIV BO - Biophysics R&D Projects GA524/06/0517 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) UT WOS 000267161000013 DOI 10.1016/j.tox.2009.03.014 Annotation In this study we provide evidence that non-dioxin-like PCB 153 congener induces degradation of several proteins participating in formation of adherens junction proteins in a model of liver progenitor cells. These effects include also inhibition of beta-catenin-dependent transcription. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2010
Number of the records: 1