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HPMA-based polymer conjugates with drug combination
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SYSNO ASEP 0325690 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title HPMA-based polymer conjugates with drug combination Title Polymerní konjugáty na bázi HPMA s kombinací léčiv Author(s) Krakovičová, Hana (UMCH-V) RID
Etrych, Tomáš (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RIDSource Title European Journal of Pharmaceutical Sciences. - : Elsevier - ISSN 0928-0987
Roč. 37, 3-4 (2009), s. 405-412Number of pages 8 s. Language eng - English Country NL - Netherlands Keywords HPMA copolymers ; drug carriers ; doxorubicin Subject RIV CD - Macromolecular Chemistry R&D Projects KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAAX00500803 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) IAA400500806 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000267479500028 DOI 10.1016/j.ejps.2009.03.011 Annotation Synthesis and physico-chemical behavior of new polymer–drug conjugates intended for the treatment of cancer were investigated. In the polymer conjugate with the expected dual therapeutic activity, two drugs, a cytostatic agent doxorubicin and anti-inflammatory drug dexamethason were covalently attached to the same polymer backbone via hydrolytically labile pH-sensitive hydrazone bonds. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2009
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