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Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers

SYSNO ASEP	0325349
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers
Title	Simultálnní doprava doxorubicinu a gemcitabinu do nádoru in vivo s využitím originálního polymerního nosiče léčiv
Author(s)	Lammers, T. (DE) Šubr, Vladimír (UMCH-V)_{RID, ORCID} Ulbrich, Karel (UMCH-V)_RID Peschke, P. (DE) Huber, P. E. (DE) Hennink, W. E. (NL) Storm, G. (NL)
Source Title	Biomaterials. - : Elsevier - ISSN 0142-9612 Roč. 30, č. 20 (2009), s. 3466-3475
Number of pages	10 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	chemotherapy ; copolymer ; drug delivery
Subject RIV	EI - Biotechnology ; Bionics
R&D Projects	1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000266744100013
DOI	10.1016/j.biomaterials.2009.02.040
Annotation	Using HPMA copolymers as a model drug delivery system, and doxorubicin and gemcitabine as model drugs, we here show that polymeric drug carriers can deliver multiple chemotherapeutic agents to tumors simultaneously. A polymer–drug conjugate carrying 6.4 wt% of gemcitabine, 5.7 wt% of doxorubicin and 1.0 mol% of tyrosinamide was synthesized, and it was shown to kill cancer cells in vitro, to circulate for prolonged periods of time, to accumulate in tumors, and to inhibit tumor growth. These findings provide in vivo evidence for the potential of polymer-based multidrug targeting, and they suggest that multifunctional polymer therapeutics might hold significant clinical potential.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2009

Number of the records: 1