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Vitamin E analogues as mitochondria-targeting compounds: From the bench to the bedside?
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SYSNO ASEP 0325048 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Vitamin E analogues as mitochondria-targeting compounds: From the bench to the bedside? Title Analogy vitaminu E jako látky zasahující mitochondrie: od laboratorního stolu k lůžku? Author(s) Zhao, Y. (CN)
Neužil, Jiří (BTO-N) RID
Wu, K. (CN)Source Title Molecular Nutrition & Food Research. - : Wiley - ISSN 1613-4125
Roč. 53, č. 1 (2009), s. 129-139Number of pages 11 s. Language eng - English Country DE - Germany Keywords Apoptosis ; cancer ; pre-clinical models Subject RIV EB - Genetics ; Molecular Biology R&D Projects IAA500520602 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000262869400011 DOI 10.1002/mnfr.200800045 Annotation Despite considerable effort focusing on designing and finding efficient anti-cancer drugs over the last decade, little progress has been achieved, in particular in case of highly recalcitrant malignancies. Since there is a trend suggesting that deaths from cancers may be more frequent than from cardiovascular diseases, it is important to look for novel efficient and selective therapeutic approaches. Redox-silent vitamin E analogues, epitomised by a-tocopheryl succinate, give some hope in the quest for drugs with such properties. Thus far, these agents have been successfully tested in experimental animals with different types of cancer, showing high efficacy against malignancies including HER2-positive breast carcinomas or malignant mesotheliomas. Further research will provide additional, necessary data to launch clinical trials, translating into development of innovative drugs acting by targeting mitochondria selectively in cancer cells Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2009
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