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The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches
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SYSNO ASEP 0324371 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of mammalian cardiac t-tubules in excitation–contraction coupling: experimental and computational approaches Title Role srdečních t-tubulů ve vazbě excitace-kontrakce u savců: experimentální a výpočtové přístupy Author(s) Orchard, C. (GB)
Pásek, Michal (UT-L) RID, ORCID
Brette, F. (GB)Source Title Experimental Physiology - ISSN 0958-0670
Roč. 94, č. 5 (2009), s. 509-519Number of pages 11 s. Language eng - English Country GB - United Kingdom Keywords cardiac cell ; t-tubules ; excitation-contraction coupling ; mathematical modelling Subject RIV BO - Biophysics CEZ AV0Z20760514 - UT-L (2005-2011) UT WOS 000265186600005 DOI 10.1113/expphysiol.2008.043984 Annotation The sarcolemmal membrane of mammalian cardiac ventricular myocytes is characterized by the presence of invaginations called transverse tubules (t-tubules). Transverse tubules occur at the Z-line as transverse elements with longitudinal extensions.While the existence of t-tubules has been known for some time, recent experimental studies have suggested that their structure and function are more complex than previously believed. There are, however, aspects of t-tubule function that are not currently amenable to experimental investigation, but can be investigated using computational and mathematical approaches. Such studies have helped elucidate further the possible role of t-tubules in cell function. This review summarizes recent experimental and complementary computational studies which highlight the important role of t-tubules in cardiac excitation–contraction coupling. Workplace Institute of Thermomechanics Contact Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Year of Publishing 2010
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