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Preparation of steroid sulfamates and their interaction with GABAA receptor
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SYSNO ASEP 0324227 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Preparation of steroid sulfamates and their interaction with GABAA receptor Title Příprava steroidních sulfamátů a jejich interakce s MNDA receptory Author(s) Kapras, Vojtěch (UOCHB-X)
Šťastná, Eva (UOCHB-X) ORCID
Chodounská, Hana (UOCHB-X) RID, ORCID
Pouzar, Vladimír (UOCHB-X)
Krištofíková, Zdena (UOCHB-X)Number of authors 5 Source Title Collection of Czechoslovak Chemical Communications. - : Ústav organické chemie a biochemie AV ČR, v. v. i. - ISSN 0010-0765
Roč. 74, č. 4 (2009), s. 643-650Number of pages 18 s. Language eng - English Country CZ - Czech Republic Keywords sulfamates ; neurosteroids ; GABAA receptors ; pregnane Subject RIV CC - Organic Chemistry R&D Projects GA203/08/1498 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000265421400010 DOI 10.1135/cccc2008187 Annotation Sulfamoyl chloride was used for the preparation of 3alpha- and 3beta-sulfamates of steroids: 20-oxo-5alpha-pregnan-3alpha-yl sulfamate (4), 20-oxo-5alpha-pregnan-3beta-yl sulfamate (5), 20-oxo5beta-pregnan-3alpha-yl sulfamate (7), and 20-oxo-5beta-pregnan-3beta-yl sulfamate (9) from the corresponding 3alpha-and 3beta-alcohols. The specific steroid binding was detected by the decrease of the specific [35S]-tert-butylbicyclo[2.2.2]phosphorothionate binding after application of the tested compounds. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2009
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