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Effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling

SYSNO ASEP	0324002
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling
Title	Vliv různých povlaků magnetických nanočástic na účinnost značení kmenových buněk
Author(s)	Horák, Daniel (UMCH-V)_{RID, ORCID} Babič, Michal (UMCH-V)_{RID, ORCID} Jendelová, Pavla (UEM-P)_{RID, ORCID} Herynek, V. (CZ) Trchová, Miroslava (UMCH-V)_{RID, ORCID} Mašínová, Katarína (UEM-P) Kapcalová, Miroslava (UEM-P) Syková, Eva (UEM-P)_RID Hájek, M. (CZ)
Source Title	Journal of Magnetism and Magnetic Materials. - : Elsevier - ISSN 0304-8853 Roč. 321, č. 10 (2009), s. 1539-1547
Number of pages	9 s.
Action	International Conference on Scientific and Clinical Applications of Magnetic Carriers /7./
Event date	20.05.2008-24.05.2008
VEvent location	Vancouver
Country	CA - Canada
Event type	WRD
Language	eng - English
Country	NL - Netherlands
Keywords	magnetic nanoparticles ; maghemite ; MRI
Subject RIV	FR - Pharmacology ; Medidal Chemistry
R&D Projects	KAN201110651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	KAN200200651 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	GA203/09/1242 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
	AV0Z50390512 - UEM-P (2005-2011)
UT WOS	000265278000048
DOI	10.1016/j.jmmm.2009.02.082
Annotation	Maghemite nanoparticles with various coatings were prepared by the coprecipitation method and characterized by transmission electron microscopy, dynamic light scattering and IR in terms of morphology, size, polydispersity and surface coating. The labeling efficiency and the viability of both rat and human mesenchymal stem cells labeled with Endorem (R), poly(L-lysine) (PLL)-modified Endorem (R), uncoated gamma-Fe2O3, D-mannose-, PLL- or poly(N,N-dimethylacrylamide) (PDMAAm)-coated gamma-Fe2O3 nanoparticles were compared. Coated gamma-Fe2O3 nanoparticles labeled cells better than did Endorem (R). High relaxation rates and in vitro magnetic resonance imaging of cells labeled with coated nanoparticles showed clearly visible contrast compared with unlabeled cells or cells labeled with Endorem (R).
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2009

Number of the records: 1