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Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways
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SYSNO ASEP 0323633 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways Title Obsah membránového cholesterolu ovlivňuje vazebné vlastnosti muskarinových M2 receptorů a produkci druhých poslů Author(s) Michal, Pavel (FGU-C) RID
Rudajev, Vladimír (FGU-C) RID
El-Fakahany, E. E. (US)
Doležal, Vladimír (FGU-C) RID, ORCIDSource Title European Journal of Pharmacology. - : Elsevier - ISSN 0014-2999
Roč. 606, 1-3 (2009), s. 50-60Number of pages 11 s. Language eng - English Country NL - Netherlands Keywords muscarinic ; cholesterol ; receptors Subject RIV ED - Physiology R&D Projects GA305/05/0452 GA ČR - Czech Science Foundation (CSF) IAA500110703 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000264988900008 DOI 10.1016/j.ephar.2009.01.028 Annotation Cholesterol depletion strongly reduced both potency and efficacy of receptor internalization, decreased efficacy of carbachol in stimulating IP accumulation and the affinity of M2 receptors for N-methylscopolamine. On the other hand increased efficacy of carbachol on cAMP synthesis Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2009
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