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Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat
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SYSNO ASEP 0323618 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat Title Delece konzervované nekódující sekvence v intronu Plzf genu způsobuje sníženou expresi Plzf v končetinových pupenech apolydaktylii u potkana Author(s) Liška, F. (CZ)
Šnajdr, P. (CZ)
Šedová, L. (CZ)
Šeda, O. (CZ)
Chylíková, B. (CZ)
Slámová, P. (CZ)
Krejčí, E. (CZ)
Sedmera, David (FGU-C) RID, ORCID, SAI
Grim, M. (CZ)
Křenová, D. (CZ)
Křen, Vladimír (FGU-C)Source Title Developmental Dynamics. - : Wiley - ISSN 1058-8388
Roč. 238, č. 3 (2009), s. 673-684Number of pages 12 s. Language eng - English Country US - United States Keywords Plzf ; polydactyly ; rat Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000264001300016 DOI 10.1002/dvdy.21859 Annotation A 2,964-bp deletion in Plzf intron 2 that was never detected in control animals represent the only candidate for the Lx polydactyly mutation. The deletion removes the most deeply conserved CNE in the 155-kb segment, suggesting a regulatory influence on Plzf expression and limb malformation determination Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2009
Number of the records: 1